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Abstract

Aluminium (Al) is a neurotoxin, and its work-related exposure can lead to Alzheimer’s disease (AD). In this case study, we describe the increased levels of Al in brain samples of a patient diagnosed with AD, who reportedly had work-related exposure to Al. In 2019, an Asian male died at the age of 64 with AD. His brain samples showed increased Al levels. The mean Al presence in tissues (n = 21) was 4.72, with a SD of 3.4 μg/g DW and a range from 0.00 – 18.35 μg/g DW. During his work in a large-scale aluminium factory, his work involved exposure to Al for five years on weekly four days basis. In our case study, we investigated the Al content of brain tissue in AD, and Al levels were seen raised and related to neurodegeneration. Work-related exposure to Al in a patient initially showed mild symptoms then lead to memory issues, and after years he was diagnosed with AD. Many clinical trials and researches are needed to find more possible effects of Al content in the human brain.

Keywords

Alzheimer’s disease (AD) Early-onset Alzheimer’s disease (EOAD) Work-related exposure to Aluminium (Al) Brain aluminium Frontal lobe (FL) tissue Dry weight (DW)

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How to Cite
Vityala Yethindra, Gulzat Mataeva, Baian Beknazarova, Furquan Nazami, Yogesh parihar, Mohammad Shaour Khalid, & Alenur Narsimharaj. (2020). A case study of Alzheimer’s disease with work-related exposure to aluminium. International Journal of Research in Pharmaceutical Sciences, 11(3), 4311-4313. https://doi.org/10.26452/ijrps.v11i3.2644