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Abstract

Taking into account the data on higher biological availability of chelate compounds of microelements in comparison with their inorganic salts, a liquid feed additive for cattle with the content of fat-soluble vitamins A, D, E and diacetophenonyl selenide (DAFS 25) in the form of stable microemulsion and chelates of manganese, iron, cobalt, and zinc was developed. The biochemical and physiologically antagonistic components of the additive are divided into two separate liquid mixtures for separate, alternating ingestion on white laboratory mice, histological methods evaluated the effect of different doses of the additive on the micro organization of the components of the stomach wall, small and large intestine in different terms of the experiment. The additive was introduced into animals individually daily per o s during one month in doses of 0.06, 0.12, 0.3, 0.6 and 1.2 g/kg. The control animals received an equivalent amount of physiological solution. The availability of trace elements of the developed product is estimated by analysis of blood serum on the zinc, iron, manganese, cobalt content by atomic-adsorption spectrometry. Examination bodies and blood for analysis were selected at the time of slaughter in accordance with generally accepted requirements. The dosage of the additive, which has the most effective influence on the growth of the concentration of injected micronutrients in the serum of mice in comparison with the control, was determined. It was found that the components of the additive have the most pronounced effect on zinc and iron content in the dose of 0.3 g/kg.

Keywords

mice blood minerals gastrointestinal tract microstructure

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How to Cite
Dmitry S. Berestov, Marina S. Kulikova, Yuri G. Vasilev, Ivan S. Ivanov, Yuri G. Krysenko, Vyacheslav B. Milaev, Elena V. Maksimova, & Sergey Yu. Smolentsev. (2020). Influence of additive components with separate introduction of antagonistic components on gastrointestinal microorganization and microelements content in mouse blood serum. International Journal of Research in Pharmaceutical Sciences, 11(3), 4182-4186. https://doi.org/10.26452/ijrps.v11i3.2625

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