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Talinum portulacifolium which is known as water plant is traditionally used for its various properties and hence in present study hydroalcoholic extract of plant leaves has been screened for its hypolipidemic activity. Hyperlipidemia is a highly prognostic risk factor for atherosclerosis, coronary artery diseases and cerebrovascular diseases. Triton WR-1339, a non ionic surfactant has been widely used to produce acute dyslipidemia in animal models in order to screen hypolipidemic activity of the extract and serum levels of various biochemical parameters such as total cholesterol, triglycerides, LDL, VLDL and HDL cholesterol and atherogenic index were determined. The animals are grouped into normal, Triton treated group, Triton + Standard, Triton + herb extract (200mg/kg) and Triton + herb extract (400mg/kg). The plant extract showed significant hypolipidemic effect by lowering all biochemical parameters and increases HDL cholesterol levels. These biochemical observations are also confirmed by Histopathological examination of liver. The plant extract also showed good antioxidant potential by increasing SOD, CAT, GSH and decreasing lipid peroxidation.
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