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The richest biosource of drugs are from the medicinal plants which are the traditional medicine. The nutraceuticals, food supplements, Siddha, Ayurveda, pharamceutical medicines, synthetic drugs are from the plant sources. Inspite of large number of studies with herbal plants which have given good correlation in the phytochemical, anti-diabetic and anti-inflammatory content, Nigella sativa- a spice plant of Ranunculacea family showed significant properties than their counterparts. The seeds of Nigella sativa and the essential oil were found to exhibit various pharmacological activities like antianalgesic, antiulcer, anti-inflammatory, antibacterial, antimicrobial, anticancer and anti-diabetic. Since there are no toxic effects or serious side effects observed using animal model and in the clinical trials, the study was carried out using Nigella sativa and Thymoquinone to find out the qualitative and quantitative phytochemical analysis, invitro - anti diabetic activity, anti inflammatory activity of Nigella sativa ethanolic extract and Thymoquinone effect on diabetes and Alzheimer’s disease. The aim of the study is to prove that the Nigella sativa could be used as therapeutic agent and the compound Thymoquinone a potential cholienesterase inhibitor for the treatment of Alzheimer’s disease.


Nigella sativa Thymoquinone Anti-diabetic Anti-inflammatory Cholinesterase inhibitor

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How to Cite
Sandhya A, & Gomathi Kannayiram. (2020). Pharmacological, bioactive screening of medicinal plant Nigella sativa and the derived compound thymoquinone : An invitro study. International Journal of Research in Pharmaceutical Sciences, 11(2), 2458-2465.