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This research work explains the antioxidant and anti-atherogenic effects of selected Siddha polyherbal decoctionssuch as Nilavembukudineer, Kabasurakudineer, NotchikudineerandAdathodaikudineer. Even though all the above decoctions have been used for fever, cold, cough, bronchitis, dysphonea and body pain in Siddha system of medicine, their antioxidant and anti-atherogenic properties were notinvestigated scientifically.We have analyzed the polyphenolic content, antioxidant and anti-atherogenic properties of decoction of the above-mentioned herbal formulations. The toxicity of the decoctions was also performed in PMBC.Inthe investigated formulations, Notchikudineershowed higher level of total phenolic content (560 mg GAE/100 g), followed byAdathodaikudineer (260 mg GAE/100 g),Nilavembukudineer(150 mg GAE/100 g) and Kabasurakudineer(90 mg GAE/100 g). Similarly, Notchikudineer exhibited strong antioxidant activity in terms of radical scavenging potential against DPPH (IC-50: 2.12 mg/L), followed the Adathodaikudineer (IC-50: 2.27 mg/L),Nilavembukudineer(IC-50: 4.48 mg/L) and Kabasurakudineer (IC-50: 9.29 mg/L).In toxicological study all the decoctions of selected formulations didn’t show any toxicity.Similarly, Nilavembukudineer showed maximum inhibition of lipid peroxidation when compared to other herbal decoctions. Among the investigated Siddha formulations, Nilavembukudineer was found to possess high antioxidant and anti-atherogenic potentials and hence it could be further investigated as anti-atherogenic drug using in vivo model.
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