Main Article Content
Orophygial candidiasis (OPC) is one of the most frequent Candida infections of the oral cavity this condition is common in patients with malnutrition, having chemotherapy, administrating immunosuppressive agents, or severe disease such as HIV. Prolong local administration of Miconazole is a must to treat OPC conditions in patients, which required the prolong mucoadhesion of the dosage form to provide local delivery of drugs for an extended time period with good mucoadhesion. Miconazole is synthetic imidazole antifungal agent, various prescription and over the counter product available like Miconazole Gel, Topical cream, Immediate release Tablet available in the market but that lack in the prolonged period of action to the local mucosa. In the present study combination of Whey protein concentrate (WPC), Hydroxypropyl methylcellulose (HPMC) and Lactose were evaluated as a potential buccal adhesive tablet. The various combination of Whey protein concentrate with release controlling polymer was tested using a Miconazole as a potential antifungal agent. The mucoadhesive potential of WPC evaluated using Tensiometer by calculating the detachment force and drug release of Miconazole was performed to study the prolong release activity of Tablet. The optimized combination of WPC/HPMC/Lactose through a statistical study showed significant bioadhesion to the porcine mucosa and prolong drug release for 10hrs.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.