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Abstract

The polycystic ovarian syndrome is associated with increases in androgen, hyperinsulinemia, secretion of a high level of luteinizing hormone, weight gain, anovulation, cyst formation, etc. Metformin is the drug used for treating PCOS with like nausea, vomiting, etc. in order to prevent the side effect and to find a better cure, and then metformin the present drug was selected   Cynodon. dactylon is commonly called as Arugampul, which is used for diabetes, antioxidant, anti-hyperlipidemic, etc. Materials and method: The animals were selected based upon the weight (125-150 gm) an oestrus cycle. 36 Wistars albino rat was taken and divided into six groups with each group six animals. Control group, Induced (PCOS) group, Referral (Metformin) group, Treatment group (C.dactylon) 500mg/kg , 1,000 mg/kg, 1,500 mg/kg. The animals were induced for PCOS first 21 days by giving Letrozole excluding the control group and examined for PCOS by vaginal smear. In the second 21 days, the animal was treated with the drug and Metformin, leaving the PCOS induced group. Results: There was a significant change with control and PCOS group, PCOS and drug & Metformin group. We were able to observe very high significant changes in lipid profile compared to hormonal and glucose profiles. Conclusion: The present study shows C. dactylon treats PCOS better than Metformin and bring backs the animals for normal condition.

Keywords

Cynodon dactylon Polycystic ovarian syndrome androgen hyperinsulinemia Total Cholesterol Triglycerides Insulin Testosterone Letrozole

Article Details

How to Cite
Anandaramajayan Nallathambi, & Rajesh Bhargavan. (2020). Biochemical and Hormonal Profile of Letrozole Induced Polycystic Ovarian Syndrome in Wistars Albino Rats treated with Cynodon dactylon. International Journal of Research in Pharmaceutical Sciences, 11(1), 1136-1141. https://doi.org/10.26452/ijrps.v11i1.1947