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Abstract

In this study, a new ligustrazine-based chalcone molecule has been synthesized that contains an extra α, β-Unsaturated ketone moiety along with α, the β-Unsaturated carbonyl group of chalone. A new tetramethylpyrazine (TMP) based aldehyde was synthesized to make the TMP (ligustrazine) as part of chalcone and then it was reacted with newly synthesized ketone containing additional α, β-Unsaturated ketone moiety. After characterization, this new compound was evaluated for its effect on different types of cancer cell lines and very promising results were obtained. The growth of these cancer cells was inhibited by newly designed and synthesized compounds, especially for colon and pancreatic cancer cells with IC50 0.04 - 0.05 µM

Keywords

Chalcone Ligustrazine Cancer Cell line Natural compound

Article Details

How to Cite
Syed Nasir Abbas Bukhari. (2020). Discovery of a new tetramethylpyrazine based chalcone with α, β-Unsaturated ketone moiety as a potential anticancer agent. International Journal of Research in Pharmaceutical Sciences, 11(1), 826-829. https://doi.org/10.26452/ijrps.v11i1.1901