Main Article Content

Abstract

Membrane lipid peroxidation and DNA, protein damage is mediated by free radicals, which form the basis of chronic pathological complications.AgNPs are an important class of nanomaterials for a wide range of biomedical applications. The present study endeavors in vitro antioxidant and anti-inflammatory activity of green synthesized silver nanoparticles (AgNPs) using medicinal plant extract from Caesalpinia bonducella seeds. Total flavonoid and phenolic contents were determined. The antioxidant potential of capped AgNPs was assessed using DPPH assay, Phosphomolybdenum assay, FRAP assay, metal chelating, hydrogen peroxide, and hydroxyl radical scavenging methods. In vitro anti-inflammatory assay of CB seed, AgNPs were performed against the standard drug. CB seed AgNPs possessed high flavonoid and phenol compared to aqueous CB seed extract. The antioxidant methods confirmed that the silver nanoparticles have more antioxidant activity as compared to vitamin C. The synthesized silver nanoparticles exhibited potential anti-inflammatory activity with the IC50 71.3µg/ml. Hence, this work clearly demonstrated that the coated AgNPs with CB seeds act as a potent free radical scavenger and could be considered as a potential source for anti-inflammatory drugs.

Keywords

CB seed AgNPs flavonoid phenol antioxidant anti-inflammatory

Article Details

How to Cite
Gloria Jemmi Christobel R, Kasi Selvi N, Shyam Sundar J., Abirami M.P., Nebita Maria Jarrett, Radhakrishnan S., Abirami S., & Shah Dupesh Khan. (2020). Assessment of in vitro Antioxidative and Anti-Inflammatory Effect of Caesalpinia Bonducella Seed Stabilized Silver Nanoparticles. International Journal of Research in Pharmaceutical Sciences, 11(1), 693-701. https://doi.org/10.26452/ijrps.v11i1.1879