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Abstract

Spectrophotometric determination of irreversible proton pump inhibitor Rabeprazole sodium has been developed, the procedure is based on the formation of 2:1 chelate of drug and metal in ethanol media to form an orange colour chelate having an absorption maximum at 455nm. The regression analysis of Beer’s law showed a good correlation in the concentration range of 10 - 60µg/ml of pure Rabeprazole with Iron (Fe+3). The limit of detection was 1.98µg/ml and limit of quantification was 6.59µg/ml. The optimum assay conditions were investigated and the recovery of the drug from their dosage forms was found to be 99.8 – 100.3%. Good values of precision were obtained, intraday R.S.D was 0.1567 and interday R.S.D was 0.1792.

Keywords

Rabeprazole sodium Spectrophotometer IronIII (Fe 3) metal chelate validation

Article Details

How to Cite
D. Madhuri, K.B. Chandrasekhar, M. Ramakotaiah, G. Somasekhar, K. Harinadhababa, & K. Ravi Kumar. (2010). Validation of Spectrophotometric determination of Rabeprazole using Ferric Chloride (FeCl3). International Journal of Research in Pharmaceutical Sciences, 1(2). Retrieved from https://pharmascope.org/ijrps/article/view/174