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Nanoparticle formulations have many advantages over traditional dosage forms, such as enhanced dissolution properties and the potential for intracellular drug delivery. Specifically, pure drug nanoparticles, polymeric nanoparticles and polyelectrolyte complexes offer some encouraging results for delivering drugs to various organs and through various routes. Traditional techniques such as spray drying and grinding, and more recent advances in supercritical fluid extraction, precipitation, and double solvent evaporation have been employed to produce nanoparticle formulations for delivery of hydrophilic & hydrophobic drugs here, the benefits of nanoparticle formulations and current progress are compared in light of the practical encumbrances of producing formulations, and possible toxicological effects of these materials.
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