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The three novel easy, to the prepare and sensitive spectral methods, were used to estimate metoclopramide in both standard and pharmaceuticals. The effective double–electron, was present in the metoclopramide compound helps to interact in an acidic medium with a reagent such as diazetide resorcinol and 8-hydroxyquinoline reagents. The present article was extended to find out three analytical methods with UV-V is the detector. In both A and B methods, two azo-dyes are formed, they are orange-red and red stable and have high water solubility, giving highest absorption values at 415 nm and 485 nm but the C method will depend on a complex colour configuration with the p-benzoquinone reagent, which has a maximum absorption at a wavelength of 285 nm. Beer's law was applied in a range of concentrations between 1 and 10 μg / ml, 2-20 μg / ml and 1-30 μg / ml. The values ​​of the molar absorption factors were (4.1224 × 104, 3.0229 × 104 and 1.7373 × 104) L mol-1cm-1 with a sensitivity of Sandell’s equal to 0.2606 × 10-4, 0.9834 × 10-4 and 0.2568 × 10 - 4 μg cm-2 to methods A, B respectively and LLOD values ​​were 0.255, 0.553 and 0.158 μg / ml to methods A, B and C. LLOQ 0.512, 0.898 and 0.455 μg / ml to methods A, B, C respectively. The constant fixed Kf configuration was also calculated for the colored outputs of the reaction where it was found to be equal to 43.6435 × 108, 54.6261 × 10-8 and 17.29099 × 106 L2 mol-2 to all methods A, B, C respectively. The values ​​of G were calculated based on -43.9293 KJ / mol, -44.3735 and -51.2019. G values, molar absorption factor, Sandell sensitivity, detection limit.


metoclopramide-HCl coupling reaction complex formation spectrophotometric studies stability constants

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Khawla Salman Abd-Alrassol, Qutaiba A. Qasim, Maitham Ali AL-Rikabi, & H. N. K. AL-Salman. (2019). The development of analytical methods to determine metoclopramide-hydrochloric acid in the standard raw and it compared with pharmaceuticals. International Journal of Research in Pharmaceutical Sciences, 10(4), 3461-3474.