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Evaluation of people at increased risk like first degree relatives of type 2 diabetes mellitus (FDRDM) may be useful to reduce the risk of disease progression, development, early intervention, and to take precautionary measures.  By considering the multifactorial pathophysiological changes of D.M., we have examined the body fat distribution, cardiorespiratory fitness, and lipid profile of FDRDM. Similar age, height, waist-hip ratio (WHR) in both groups, significantly higher body mass index (BMI) in FDRDM, was observed in our study. Percentage body fat and blood glucose levels in fasting were elevated considerably, and 12 min walk distance was low in FDRDM. Visceral fat was slightly high, but it was not statistically significant. In FDRDM, High-density lipoproteins (HDL) were less but not statistically significant. Significantly higher levels of  Total cholesterol (T.C.), triglycerides (TGL), low-density lipoproteins (LDL), and very-low-density lipoproteins (VLDL) were seen high in FDRDM when compared to controls. Higher body fat percentage reduced cardiorespiratory function and abnormal lipid profile in FDRDM may lead to the development of severe cardiovascular events and necessitates lifestyle modification at early phases of disease development.


Body fat cardiorespiratory fitness high-density lipoproteins visceral fat

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Shaik Azmatulla, Rinku Garg, Anil Kumar Sharma, & Navpret Mann. (2019). Body fat distribution, cardiorespiratory fitness, and lipid profile in first degree relatives with type 2 diabetes mellitus. International Journal of Research in Pharmaceutical Sciences, 10(4), 3293-3296.