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Irbesarton is a widely prescribed drug for Hypertension. A simple, rapid and precise ultraviolet spectroscopy method was developed and validated for quantitative analysis of irbesarton in bulk drug. It is an angiotensin II receptor (AT1 subtype) antagonist. It is used for the treatment of hypertension. The mean percentage was found to be in a range of 99.35%-100.45%. Beer`s law was obeyed in the concentration range of 5-40µg/ml. calibration curves shows a linear relationship between the absorbance and concentration. It shows maximum absorbance at 207.16 nm. The line equation y=0.022+0.036 with R2=0.999 was obtained. The method was successfully validated in accordance to ICH guideline for accuracy, precision, linearity, LOD, and LOQ. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor is greater than 0.999 for irbesarton. The % Recovery/Accuracy was within the range between 98% and 102%. The percentage RSD for precision was found to be less than 2%. Thus method was successfully applied for routine analysis of irbesarton in bulk samples.               


Irbesarton ultraviolet spectroscopy hypertension precision linearity

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How to Cite
Swathi P, Rajesekhar C, Sudheer Kumar Y, Nusrath Sulthana S, Sushma S, Mohammed Ishaq B, & Hindustan Abdul Ahad. (2016). Method development and validation of a simple uv spectrometric method for the quantification of irbesarton in bulk and its tablets . International Journal of Research in Pharmaceutical Sciences, 7(1), 39-42. Retrieved from