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The aim of this research was to determine influence of proniosome system which consists of ibuprofen-span 60-cholesterol with molar ratio of 2:1:0,75. The proniosome system was made by Coacervation Phase Separation Method, using ethanol 96% as solvent and glycerol 0,1% as aqueous phase. There were two formulas in this research formula I was ibuprofen non proniosome in HPMC gel base and formula II was ibuprofen proniosome in HPMC gel base. Characterization of formulas included organoleptic and pH of ibuprofen gel. Drug release was determined using difussion cell and cellophane membrane in phosphate buffer pH 6,0 ± 0,05 at temperature 32 ± 0,5oC for 8 hours. The drug release (flux) of ibuprofen from formula I and II were 28,3067 ± 3,0852 µg/cm2/min½ and 23,1900 ± 1,7 658 µg/cm2/min½, respectively. The statistical result using independent sample T-test on degree of confident of 95% (α = 0,05) concluded that there was significant value of their fluxs. Research result revealedthat release of ibuprofen proniosome system was lower than ibuprofen nonproniosome system in HPMC 4000 gel base.
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