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Abstract

The present study Formulation and invitro Characterization of Floating microspheres of Repaglinide has been carried with an aim to improve the drug’s bioavailability by delaying its gastric residence time. Repaglinide, an oral hypoglycemic agent used for the treating Type II diabetes has been chosen as a model drug for these studies. Microspheres were prepared by Solvent evaporation method employing different concentrations of polymers such as sodium alginate, HPMC K100, sodium carbonate and effect of these polymers on the formulation parameters of drug was studied. Obtained microspheres were studied for micromeritic properties such as Angle of Repose, Hausner’s ratio, Carr’s index, Bulk and Tapped density. In addition, in-vitro evaluation studies for microspheres were carried like % entrapment efficiency, drug-polymer compatibility, in-vitro buoyancy, SEM studies and in-vitro drug release studies. Results of FT-IR and SEM studies demonstrated that drug and polymer have not interacted and all the microspheres were spherical and smooth in nature. Data obtained from in-vitro release studies showed F5 formulation retarded drug release over a period of 8hrs and is considered an ideal formulation. Ideal formulation when observed for kinetic studies indicated that F5 followed Korsmeyer-peppas release kinetics.               

Keywords

Microspheres Repaglinide Sodium alginate HPMC K100 Sodium bicarbonate Carr’s index Hausner’s ratio

Article Details

How to Cite
Narasimha Rao B, Kasim Vali D.S, Gnana Prakash K, Viswanath V, Sai Padmini D, & Rahath Fathima S. (2016). Formulation and in vitro characterisation of repaglinide floating microspheres . International Journal of Research in Pharmaceutical Sciences, 7(4), 285-291. Retrieved from https://pharmascope.org/ijrps/article/view/1287