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The present study investigates the Isolation and insilico evaluation of Artemisinin from ethanolic extract of Artemisia indica Willd for antidiarrhoeal activity is a medicinal plant which has been valued for centuries in ayurvedic medicine. Phyto-chemical screening of Artemisia indica plant extracts revealed the presence of various active constituents such as alkaloids, flavonoids, flavanones, Carbohydrates, steroids and terpenoids. Since terpenoids have remarkable anti-diarrhoeal activity, our present work aims at evaluating the anti-diarrhoeal activity of Artemisinin which is a sesquiterpenoid lactone isolated from Artemisia indica by thin layer chromatography and evaluated by docking studies. The results of our studies suggests that artemisinin showed more anti-diarrhoeal activity than the standard drug loperamide when binded with the µ opioid receptors. Therefore our results support the use of artemisinin in treating diarrhoea in animal studies. We hope it might become a good antidiarrhoeal drug in future.
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