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The aim of the present study was to investigate the potential of nano-emulsion (thermodynamically stable, transparent, dispersion of oil and water having droplet size less than 200nm). Formulation of self-Emulsifying system of Dronedarone as a model drug, by using Myristic acid isopropyl ester, Tween80, Ethanol as oil phase, surfactant and co-surfactant respectively and water. Various o/w nano-emulsion formulations were prepared by spontaneous self- emulsification method. The area of nano emulsions were identified by constructing pseudo ternary phase-diagrams. The nano-emulsions that were prepared subjected to thermodynamic stability testing. The tests were characterized by using droplet size, Scanning electron Microscopy (SEM), viscosity, zeta potential and pH and in-vitro dissolution studies. The in-vitro dissolution studies of optimized formulation was compared with nanoemulsion. Thus these results suggested that nano-emulsions are the key vehicles for improved emulsification delivery of Dronedarone.
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