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The aim of the present study was to formulate and evaluate Pioglitazone hydrochloride pellets. The Pioglitazone hydrochloride immediate and controlled release pellets were prepared by solution/suspension layering technique by using croscarmellose in IR layer and three different polymers such as Ethyl cellulose, Eudragit L100, Xanthan gum as rate controlling polymers in four different ratios like 1:0.5,1:1, 1:1.5 and 1:2 to achieve desired drug release in CR layer. Evaluation was performed according to the pharmacopoeia standards including drug excipient compatibility, percentage yield, particle size distribution, drug content analysis and in-vitro drug release study. The best results were shown in F11 Pioglitzone and Eudragit L100 in1:1.5 ratios. A broad variety of drug release pattern could be achieved by variation of polymer ratios which was optimized to match the target release profile. In comparision of in-vitro release studies for all developed controlled release formulations, F11 relelases 97.50% of drug at the end of 12th hour and was considered as best formulation.
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