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Liver disorder is one of the familiar health troubles and it is exposed to several category of xenobiotics and therapeutic agents. The present research was designed to investigate the possible Hepatoprotective effect of Ethanolic extract of Cucumis sativus L. (EECS) against the paracetamol-induced hepatotoxicity. The EECS at 150 mg/kg, p.o. showed a significant hepato protective activity against, paracetamol-induced hepatotoxicity as judged by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP). The serum levels of total proteins and bilirubin were also estimated in treatment of rats with dose level of 150mg/kg of plant extract. Significantly (P < 0.001) changed serum marker enzymes levels closer to normal against paracetamol treated rats. The activity of the EECS at dose of 150 mg/kg was nearly comparable to the standard drugsilymarin (25 mg/kg, p.o.). A histopathological study of liver exhibited almost normal architecture, when compared to paracetamol treated group. The present study showing that EECS has significant hepato protective effect against paracetamol-induced hepato toxicity in rats
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