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Abstract

In the present research, an attempt has been made to formulate sustained release matrix tablets of Atorvastatin Calcium, a novel statin reported to reduce the morbidity and mortality of cardiovascular diseases, which shows poor bioavailability (12%) and low aqueous solubility (BCS Class II). The matrix tablets were prepared by direct compression method using natural polymers (Xanthum gum -F1, F2, Guar gum -F3, F4, Carragenan -F5, F6) and synthetic polymers (HPMC-K100M -F7, F8 and HPMC- 50 cps -F9, F10) at various concentrations and its effect were compared. The tablets were subjected for weight variation, hardness, thickness, friability, drug content uniformity, in vitro dissolution and FT-IR studies. All the formulations showed compliance with pharmacopoeia standards and the FT-IR spectrum shows compatibility of the drug with excipients. The cumulative drug release for F2, F4 and F6 was 72%, 98% and85% up to 17 h indicating the retarded release due to higher concentration (60 mg) of natural polymers than the other batches and its t50% values were found to be 12 ½ h and 8 h. The drug release mechanism was found to be Korsmeyers and Peppas model (R2=0.9022) for F2 and zero order (R2=0.9244) for F4 and (R2=0.9348) for F6. The formulations F2, F4 and F6 which was prepared by natural polymers were optimized for the formulation of sustained release matrix tablets of Atorvastatin Calcium.

Keywords

Atorvastatin Carrageenan Guar gum Sustained release Xanthan gum

Article Details

How to Cite
Gowtham T, Punitha S, Thrishala B, Soujanya P, & Rajasekar S. (2013). Formulation and evaluation of Atorvastatin calcium sustained release matrix tablets. International Journal of Research in Pharmaceutical Sciences, 4(1), 82-87. Retrieved from https://pharmascope.org/ijrps/article/view/1121