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The purpose of this study was to evaluate the anti-inflammatory activity of the ethanolic fruit extract of Anamirta Cocculus in experimental acute and sub acute inflammatory models. Ethanolic extract of fruit of Anamirta Cocculus was prepared and tested for anti-inflammatory activity in Albino Wister rats weighing 200-250 grams. The animals were randomly divided into three groups of 6 each; one group served as control and other two groups received diclofenac and ethanolic extract of Anamirta Cocculus orally 1 hr prior to experimentation. The in-vivo anti-inflammatory activity was studied using the acute (Carrageenan induced paw edema, Histamine induced paw edema) and sub acute (Cotton pellet induced granuloma) animal models. Anti-inflammatory activity was expressed as Percent inhibition (pI). Statistical analysis was performed using One-way analysis of variance (ANOVA) followed by Dunnett’s Multiple Comparison Test P<0.001 was considered statistically significant. The maximum PI with diclofenac and ethanolic extract of AC in Carrageenan induced paw edema were 60.56% and 58.83%, in histamine induced paw edema 58.63% and 60.27% and in cotton pellet induced granuloma were 53.11% and 36.08% respectively. Diclofenac showed highly significant activity in all the three models. However, ethanolic extract of AC showed highly significant activity in all the three models studied. As ethanolic extract of AC showed significant anti-inflammatory activity in the models studied, it can be a promising anti-inflammatory agent.
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