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Lomefloxacin hydrochloride is a fluoroquinolone antibiotic used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Although lomefloxacin is not rapidly absorbed after oral administration its half life is 8 hr., it is critical to improve the dissolution rate to enhance the bioavailability, due to its low water solubility. Solid dispersions of lomefloxacin hydrochloride with polyvinyl pyrrolidone (PVP K30) and HPMC K4M and Urea were prepared by using fusion method. The prepared solid dispersions using urea were free flowing and showed good percentage of drug content (96%w/w). The FTIR study reveals no chemical interaction between lomefloxacin hydrochloride and carriers used. The XRPD and DSC studies confirm transformation of crystalline form of lomefloxacin hydrochloride into the amorphous form. The in vitro dissolution studies of formulated solid dispersions shows the increase in solubility in order of Urea> PVP> HPMC.
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