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Tramadol hydrochloride is a centrally acting synthetic opioid analgesic used in treatment of moderate to severe pain. Tramadol is chemically (1R,2R)-rel-2-[(dimethylamino)methyl]- 1-(3-methohxyphenyl) cyclohexanol. Tramadol Hcl Floating tablet containing tramadol HCl were prepared to have gastroretention in the upper region of stomach with objective of prolongation of the drug release at this region with aim of prolongation of residence time by the candidate due to its low half life with severity of the existing pain. In the present study the dosage forms of floating drug delivery system is tried with different excipients with different grades of polymer of hypromellose like HPMC K 4M, HPMC K 15 M and HPMC K 100 M with varying proportion of disintegrating agent and superdisintegrant along with the gas generating agent such as Sodium bicarbonate. Thus prepared batches of different formulations were subjected for its release kinetics fitted with different kinetic equations the percentage drug release and the effect of superdisintegrant was found that the tramadol Hcl floating tablet is a promising approach as it can lead to decrease in the frequency of administration and increase the residence time in the stomach.


Tramadol HCl Floating drug delivery Gastro-retentive delivery Super-disintegrant

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How to Cite
Ravi M, & Narayanan N. (2012). Formulation and in vitro evaluation of gastro retentive drug delivery system of tramadol hydrochloride. International Journal of Research in Pharmaceutical Sciences, 3(4), 503-508. Retrieved from