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Eye diseases are commonly encountered in a day to day life, which are most interesting and challenging for scientists. A newly development and particulate vesicular systems like liposomes, pharmacosomes and discomes are useful in delivering the drug for longer extent and helpful in systemic circulation. When the eye drops is administered in the inferior fornix of the conjunctiva, a very minute amount of the dose reaches to the intraocular tissues and major fraction of the administered drug get washed away with the lachrymal fluid or absorbed systemically in the nasolacrimal duct and pharyngeal sites. The unique anatomy and physiology which content various type of barrier such as the different layer of cornea, sclera and cornea and retina. Including blood aqueous and blood retinal barrier, coroidal and conjuctival blood flow these review focuses on recent development in the convectional ophthalmic drug delivery system for eye having eye drop, eye ointment, aqueous gel, solid matrices and devices, nano-suspension,nano-particles, liposomes, neosomes, and ion-tophorosis to improve ophthalmic bioavailability of drug to an anterior chamber of the eye. Ocular drug delivery system provides the delivery of genes, and proteins to internal structure, which is inaccessible. In these review non conventional technologies such as nanotechnology, microspheres, micro-emulsion and ocular inserts would be developed in the pharmaceutical market.
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