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Abstract

Chrysin (5,7-dihydroxy flavone) possesses diverse pharmacological effects including anticancer potential. Aim of the present investigation was to assess the chemopreventive potential of chrysin in 7, 12-dimethylbenz (a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. Skin tumors in mice were developed by painting with DMBA two times a week for 8 weeks. Hundred percent tumors was noticed in mice treated with DMBA alone after 14 weeks. Though oral administration of chrysin at a dose of 250 mg/kg bw to mice treated with DMBA significantly (86.6%) prevented tumor formation, severe hyperplasia, hyperkeratosis and dysplasia was noticed. The present results suggest that chrysin might have delayed rather than inhibiting the tumor formation during DMBA-induced skin carcinogenesis.

Keywords

Chemoprevention DMBA Skin cancer Chrysin

Article Details

How to Cite
Murugaraj Manoj Prabhakar, Shanmugam Manoharan, Nagarethinam Baskaran, Ramachandran Srinivasan, Sekar Karthikeyan, & Shamsul Afaq Wani. (2012). Chemopreventive potential of chrysin in 7, 12-dimethylbenz(a)anthracene in-duced skin carcinogenesis in Swiss albino mice. International Journal of Research in Pharmaceutical Sciences, 3(1), 89-96. Retrieved from https://pharmascope.org/ijrps/article/view/1002